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Research is shining a light on B cells as the source of IgAN pathogenesis

Blue kidneys icon

IgAN is a serious and
progressive autoimmune
disease

While optimized supportive care is beneficial
for patients with IgA nephropathy (IgAN),
many may still experience progressive decline
of estimated glomerular filtration rate (eGFR)
that eventually leads to kidney failure.1

Blue and white cells icon

IgAN is a B cell–mediated
kidney disease

Cytokines B cell activating factor (BAFF)
and a proliferation-inducing ligand
(APRIL) play a crucial role in IgAN
pathogenesis by regulating
B cell function.1

Papers icon

The role of BAFF and APRIL
in IgAN pathogenesis

This review article discusses various preclinical and
clinical studies that highlight the potential role of
BAFF and APRIL in the pathogenesis of IgAN.

Dialysis chair icon

Patients with IgAN are
at high risk of kidney failure
within their lifetime

Almost all patients diagnosed under the
age of 50 with eGFR decline of
3 mL/min/year will reach kidney failure.2

What’s your IgAN IQ?

Answer these 5 questions
to find out

answer

Your answer:

Correct answer:

Your Score
/5

Question 1

Approximately of adult patients with IgAN develop kidney failure or die within 20 years of diagnosis.

Your Answer:

Correct Answer: D: 75%

Question 2

Around of patients with IgAN with proteinuria 0.44 to < 0.88 g/g (~0.5 to 1.0 g/day) progress to kidney failure within 10 years.

Your Answer:

Correct Answer: B: 30%

Question 3

High Gd-IgA1 levels are associated with a greater risk of .

Your Answer:

Correct Answer: D: All of the above

Question 4

Which of the following are independent risk factors for IgAN progression?

Your Answer:

Correct Answer: C: Proteinuria and hematuria

Question 5

Which of the following is the earliest step in the pathogenesis of IgAN?

Your Answer:

Correct Answer: C: Upregulation of cytokines BAFF and APRIL

 
 
 
 
 

Approximately of adult patients with IgAN develop kidney failure or die within 20 years of diagnosis.

Around of patients with IgAN with proteinuria 0.44 to < 0.88 g/g (~0.5 to 1.0 g/day) progress to kidney failure within 10 years.

High Gd-IgA1 levels are associated with a greater risk of .

Which of the following are independent risk factors for IgAN progression?

Which of the following is the earliest step in the pathogenesis of IgAN?

References:

  1. Cheung CK et al. The role of BAFF and APRIL in IgA nephropathy: pathogenic mechanisms and targeted therapies. Front Nephrol. 2024;3:346769. doi: 10.3389/fneph.2023.1346769.
  2. Pitcher D et al. Long-term outcomes in IgA nephropathy. Clin J Am Soc Nephrol. 2023;18(6):727–738.
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